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What is meant by Cannabidivarin (CBDV) | How CBDV Works
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[Image: cannabidivarin.png]

When we go to talk about the compounds that are present in cannabis, it is extremely easy to get hung up on CBD & THC. After all, these all are the main constituents of the plant. However, there are hundreds of compounds present in cannabis that in spite of their small presence, can have a huge impact on how the plants actually affect us. CBDV or Cannabidivarin is one such chemical.

CBD and THC have stolen the spotlight of the cannabis conversation. The ancient cannabis plants are containing hundreds of compounds. Many of these are eligible in interacting in unique ways for delivering endless benefits. In this article, you will know about cannabidivarin or CBDV which is one highly underestimated cannabinoid with lots of potentials.

What is meant by CBDV?

CBDV is one of those more than 100 cannabinoids that are produced by the cannabis plant. Like another secondary cannabinoid, CBDV is basically found in lower concentrations than CBD and THC, and typically these tend to be more present in low-THC varieties of cannabis, such as hemp.

CBDV is a popular non-intoxicating cannabinoid. It means that it does not do the production of the euphoric high or sleepy stone. It typically gets associated with cannabis varieties that are rich in THC. CBD is a homolog to CBDV, and both these compounds used to share extremely similar chemical mechanisms and structures of action.

How Does CBDV Actually Work?

As it is with many cannabinoids, there are still a huge number of things that we don't know about CBDV and the mechanisms of action it. However, preliminary trials on this cannabinoid facilitate us with at least some idea of how it might act on the body of humans.

Like the cannabinoid cousin (CBD) of it, CBDV is not indulged in showing a high affinity for cannabinoid receptors that are CB1 and CB2 respectively. It is one of the main reasons that it does not do the production of the intoxicating effects which are basically associated with cannabis.

Studies have revealed that just like CBD cannabidivarin might act on other chemical pathways and get interacted with the endocannabinoid system of humans in a much more indirect fashion.

For instance, clinical trials that are investigating the efficacy of CBDV in the treatment of epilepsy and convulsions symptoms give the suggestion. The suggestion is that CBDV used to activate and desensitizes TRPV1 receptors both of which are also known as capsaicin receptors.

It plays a very crucial role in our ability to sense pain and perceived temperature. Other studies reveal that CBDV might act on TRPA1 and TRPV2 receptors.

All these receptors usually fall under the category of transients receptor potential channels. These channels are known for being embedded into the cell membrane. And when these are activated you are required to open it for facilitating ions for flowing into a cell such as sodium.

Researches have also shown that CBDV might interfere with the activity of diacylglycerol lipase. It is one of the key enzymes that are involved in the synthesis of 2-AG. It is an endocannabinoid that is naturally produced by the body. However, it is completely clear that actually how does CBDV do it.

What Does CBDV Actually Do

CBDV has been a point of focus for a huge variety of different trials and studies. However, we are still less aware of this cannabinoid, the mechanisms of action it, and the therapeutic potential than we do about CBD. Here you will come to know about some of the research on CBDV. You will also examine that it would tell you about the functions it and the potential of it. You are required to keep in your mind that all of these results are preliminary.

Epilepsy and CBDV

The British Journal of Pharmacology has published a study in which he has examined the effects of CBDV on mice and rats. The animals were provided cannabis plant-derived extracts in numerous doses. These doses were rich in CBDV and these have also contained CBD, as well as pure forms of both cannabinoids.

The researchers have also made use of an isobologram analysis. It was for the determination of how the two cannabinoids actually interact, and for getting a better understanding of their individual effects on their body.

The mice and rats were then made for having seizures by making use of pentylenetetrazole which is a respiratory and circulatory stimulant, audiogenic seizure model (in this model animals were placed in an isolated chamber, after that they were exposed to an acoustic stimulus that was known for evoking a seizure), and pilocarpine.

The researchers have made use of this for the determination of the anticonvulsant potential of CBDV rich extracts. The results from the isobologram analysis have revealed that the cannabinoid has delivered the effects without acting on CB1 receptors.

CBDV & Autism

Given the potential of CBDV in the modulation of the inhibitory and excitatory systems in the brain. Some of the studies have looked into the therapeutic potential in addressing the core symptoms of autism spectrum disorder.

In the year 2019, the journal of Translation Psychiatry has taken the premise. They have put it to the test by seeing that if CBDV is eligible in affecting GAMA and glutamate metabolites which are the markers of the excitatory or inhibitory systems of the brain. And both of these healthy individuals and patients who were having autism spectrum disorder.

The study has followed a randomized-order, double-blind, cross-over design, and has made use of magnetic resonance spectroscopy. It was for the measurement of the glutamate and GABA+ levels in the brains of 34 male participants. Out of these 17 participants were those who were having autism and 17 were those who were without autism. They have followed the treatment with a placebo & a single dose
of 600mg of CBDV.

The researchers of the study have claimed that CBDV was having an effect on glutamate levels in the brains of both groups of participants. Unluckily, the effects of it were not at all uniform across the individuals. And the authors have concluded that further studies were required for properly determining the potential of CBDV as a treatment for the symptoms of autism spectrum disorder.

CBDV & Nausea

Many people have reported that making use of cannabis while you are experiencing nausea, vomiting, or upset stomach. Thus, there has been a growing interest in testing how cannabinoids might interact with the natural nausea response of our body.

In 2013, the British Journal of Pharmacology has published a comparative study which has examined the antiemetic potential of CBDV in animal models of nausea. The authors of the study have first made use of two inverse agonists of the CB1 receptor for inducing nausea in lab rats. After that, they have run two experiments for seeing whether the THCV and CBDV have either induced nausea or they have reduced it.

Ultimately, the study has claimed that neither CBDV nor THCV has worked as CB1 reverse agonists. As a result of which it has appeared for the reduction of the markers which were associated with the upset stomach in the test subjects.

Is CBDV having any side effects?

CBDV has not shown that it does the production of any side effects. However, it does not mean that is basically devoid of any adverse effects. Simply, we have the requirement of more research for the determination of the safety profile of cannabinoids.
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