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It was the discovery of melatonin synthesis in endocrine organs, particularly the pineal gland, neural frameworks, as well as immunocompetent cells such as T lymphocytes, NK cells, and mast cells that caused the brand-new strategies to the unifield signal law of homeostasis, which, at the turn of the 21st century, cause the creation of a new indispensable biomedical self-control - neuroimmunoendocrinology.
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