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It was the exploration of melatonin synthesis in endocrine organs, particularly the pineal gland, neural frameworks, and immunocompetent cells such as T lymphocytes, NK cells, and mast cells that activated the new strategies to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, result in the development of a new integral biomedical technique - neuroimmunoendocrinology.
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