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It was the discovery of melatonin synthesis in endocrine body organs, particularly the pineal gland, neural frameworks, as well as immunocompetent cells such as T lymphocytes, NK cells, and also mast cells that activated the brand-new approaches to the unifield signal law of homeostasis, which, at the turn of the 21st century, bring about the production of a brand-new integral biomedical technique - neuroimmunoendocrinology.
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