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It was the exploration of melatonin synthesis in endocrine organs, namely the pineal gland, neural frameworks, as well as immunocompetent cells such as T lymphocytes, NK cells, and mast cells that activated the new strategies to the unifield signal policy of homeostasis, which, at the turn of the 21st century, result in the production of a brand-new important biomedical discipline - neuroimmunoendocrinology.
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