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It was the discovery of melatonin synthesis in endocrine organs, specifically the pineal gland, neural frameworks, and also immunocompetent cells such as T lymphocytes, NK cells, as well as mast cells that triggered the brand-new strategies to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, lead to the production of a brand-new essential biomedical discipline - neuroimmunoendocrinology.
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